William McCulloch was of Highland descent, but lived in Paisley all his life. At one time he wanted to be a lawyer, but instead he worked in the local Parish Council, collecting rates. In his spare time he was interested in amateur dramatics and opera, appearing in a number of comic roles (he was principal comedian with the Glasgow Orpheus Club).

After leaving the Parish Council, McCulloch became a professional entertainer, and for twenty five years he travelled throughout Scotland and beyond, reciting his monologues to hugely appreciative audiences. The monologues were also popular when released on 78rpm records. Some of these are listed at Willie McCulloch's discography page.